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Insaf Ahmed Qureshi

    Dr. Insaf Ahmed Qureshi
    Assistant Professor
    Department of Biotechnology & Bioinformatics
    School of Life Sciences
    University of Hyderabad,
    Prof. C.R.Rao Road, Gachibowli,
    Hyderabad, 500046, India
    Ph.No. +91-40-23134588 (Off.) +91-40-23134688 (Lab)
                               Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

Education:
  M.Sc. Microbiology    - Jiwaji University, Gwalior, India
  Ph.D. Biotechnology  - Hamdard University, New Delhi, India

Research Interests:

The main focus of my research is on the three-dimensional structure determination of proteins, as well as studies on the structure-function relationships. To this end, I use a combination of biochemical and X-ray crystallographic methods. My research is focused on proteins of immunological significance like bacterial, viral, protozoan proteins, anti combodies and theirplexes.


Awards/Achievements/Positions held:

  • Awarded for Indo-US Raman Fellowship by University Grant Commission (UGC), New Delhi for year 2013-2014.
  • Awarded for ICMR Prize-2010 by Indian Council of Medical Research (ICMR), New Delhi for year 2010.
  • Selected for International Exchange Programme by Indian National Science Academy (INSA), New Delhi for year 2013-2014. 
  • Assistant Professor, Department of Biotechnology, University of Hyderabad, Hyderabad, India (2010-Present).
  • Postdoctoral Research Fellow, School of Biological Sciences, Nanyang Technological University, Singapore (2007-2010).
  • Project Associate, National Institute of Immunology, New Delhi, India (2005-2007).

Selected Publications:

  1. Robinson R, Qureshi IA, Klancher CA, Rodriguez PJ, Tanner JJ, Sobrado P (2015). Contribution to catalysis of ornithine binding residues in ornithine N5-monooxygenase. Arch Biochem Biophys 585:25-31.
  2. Bimolata W, Kumar A, Reddy SK, Sundaram RM, Laha GS, Qureshi IA, Ghazi IA (2015). Nucleotide diversity analysis of three major bacterial blight resistance genes in rice. PLoS One 10(3):e0120186.
  3. Kumar A, Bimolata W, Qureshi IA, Ghazi IA (2015). Comparative proteomics reveals differential induction of both biotic and abiotic stress response associated proteins in rice during Xanthomonas oryzae pv. oryzae infection. Functional & Integrative Genomics 15(4):425-437.
  4. Da Fonseca I*, Qureshi IA*, Mehra-Chaudhary R, Kizjakina K, Tanner JJ, Sobrado P (2014). Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics. Biochemistry 53(49):7794-804. *Equally contributed
  5. Uppalapati SR, Kingston JJ, Qureshi IA, Murali HS, Batra HV (2013). In silico, in vitro and in vivo analysis of binding affinity between N and C-domains of Clostridium perfringens alpha toxin. PLoS One 8(12):e82024.
  6. Kumar A, Gul MZ, Zeeshan A, Bimolata W, Qureshi IA, Ghazi IA (2013). Differential antioxidative responses of three different rice genotypes during bacterial blight infection. Australian Journal of Crop Sciences 7(12): 1893-1900.
  7. Kumar A, Lewin A, Rani PS, Qureshi IA, Devi S, Majid M, Kamal E, Marek S, Hasnain SE, Ahmed N (2013). Dormancy Associated Translation Inhibitor (DATIN/Rv0079) of Mycobacterium tuberculosis interacts with TLR2 and induces proinflammatory cytokine expression. Cytokine 64(1):258-64.
  8. Bimolata W, Kumar A, Sundaram RM, Laha GS, Qureshi IA, Reddy GA, Ghazi IA (2013). Analysis of nucleotide diversity among alleles of the major bacterial blight resistance gene Xa27 in cultivars of rice (Oryza sativa) and its wild relatives. Planta 238(2): 293-305.Gul MZ,
  9. Ahmad F, KondapiAK, Qureshi IA, Ghazi IA (2013). Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts -an in vitro study. BMC Complementary & Alternative Medicine 13: 53.
  10. Alag R, Balakrishna AM, Rajan S, Qureshi IA, Shin J, Lescar J, Grüber G, Yoon HS (2013). Structural insights into substrate binding by PvFKBP35, a peptidylprolyl cis-trans isomerase from the human malarial parasite Plasmodium vivax. Eukaryotic Cell 12(4): 627-34.
  11. Gul MZ, Attuluri V, Qureshi IA, Ghazi IA (2012). Antioxidant and α-glucosidase inhibitory activities of Murraya koenigii leaf extracts. Pharmacognosy Journal 4(32): 65-72.
  12. Kumar A, Majid M, Kunisch R, Rani PS, Qureshi IA, Lewin A, Hasnain SE, Ahmed N (2012). Mycobacterium tuberculosis DosR Regulon Gene Rv0079 Encodes a Putative, ‘Dormancy Associated Translation Inhibitor (DATIN)’. PLoS One 7(6): e38709.
  13. Salman M, Malleda C, Suneel NA, Qureshi IA, Frank EA, D’Souza CJM (2011).Homology modeling of human serum paraoxonase1 and its molecular interaction studies with aspirin and cefazolin. Bioinformation 7(2): 59-63.
  14. Gul MZ, Bhakshu LM, Ahmad F, Kondapi AK, Qureshi IA, Ghazi IA (2011). Evaluation of Abelmoschus moschatus extracts for antioxidant, free radical scavenging, antimicrobial and antiproliferative activities using in vitro assays. BMC Complementary & Alternative Medicine 11(1): 64.
  15. Alvi A, Ansari SA, Ehtesham NZ, Rizwan M, Devi S, Sechi LA, Qureshi IA, Hasnain SE, Ahmed N (2011). Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986) points to its role in chronic persistence. PLoS One 6(7): e22530.
  16. Smith HL, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC (2011). The role of TBK1 and IKKε in the expression and activation of Pellino1. Biochemical Journal 434(3): 537-48.
  17. Yoon HS, Alag R, Kang C, Ye H, Kotaka M, Qureshi IA, Bharatham N, Shin J, Bozdech Z, Preiser P, Lescar J. (2010). Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics. Malaria Journal 9(Suppl 2): P60.
  18. Liew CW, Sharff A, Kotaka M, Kong R, Sun H, Qureshi IA, Bricogne G, Liang ZX, Lescar J (2010). Induced-fit upon ligand binding revealed by crystal structures of the hot-dog fold thioesterase in dynemicin biosynthesis. Journal of Molecular Biology 404(2): 291-306.
  19. Alag R*, Qureshi IA*, Bharatham N, Shin J, Lescar J, Yoon HS (2010). NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35. Protein Science 19(8): 1577-86. * Equally contributed.
  20. Gaur V, Qureshi IA, Singh A, Chanana V, Salunke DM (2010). Crystal structure and functional insights of hemopexin fold protein from grass pea. Plant Physiology 152(4): 1842-50.
  21. Anandhan S, Qureshi IA, Koundal KR (2010). The cowpea trypsin inhibitor promoter drives expression in response to cellular maturation in Arabidopsis thaliana. Physiology & Molecular Biology of Plants 16(1): 31-37.
  22. Qureshi IA, Ferron F, Seh CC, Cheung P, Lescar J (2009). Crystallographic structure of ubiquitin in complex with cadmium ions. BMC Research Notes 2: 251.
  23. Kotaka M, Kong R, Qureshi IA, Ho QS, Sun H, Liew CW, Goh LP, Cheung P, Mu Y, Lescar J, Liang ZX (2009). Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis. Journal of Biological Chemistry 284(23): 15739-49.
  24. Qureshi IA, Dash PK, Srivastava PS, Koundal KR (2007). Isolation and characterization of a lectin gene from seeds of chickpea (Cicer arietinum L.). DNA Sequence 18(3): 196-202.
  25. Qureshi IA, Dash P, Srivastava PS, Koundal KR (2006). Purification and characterization of an N-acetyl-D-galactosamine-specific lectin from seeds of chickpea (Cicer arietinum L.). Phytochemical Analysis 17(5):350-6.
  26. Qureshi IA, Sethi DK, Salunke DM (2006). Purification, identification and preliminary crystallographic studies of an allergenic protein from Lathyrus sativus. Acta Crystallography F 62: 869-72.