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Bramanandam

   Bramanandam Manavathi, Ph.D(Assistant Professor)
    Department of Biochemistry
    School of Life Science
    University of Hyderabad,
    Prof. C.R.Rao Road, Gachibowli,
    Hyderabad, 500046, India
    Tel: Mob: 040-2313 4546
    Fax:040-231010120
    Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it. ; This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

Education                                        

MSc & PhD (Biochemistry) – Sri Krishnadeveraya University (1995-2002)

 Awards/Achievements/Position held

  • Asst Professor, University of Hyderabad, Hyderabad (2007-Present)
  • Postdoctoral Research Fellow, University of Texas, Institute of Molecular Medicine (2002-2003)
  • Postdoctoral Research Fellow, University of Texas, MD Anderson Cancer Center, Houston, USA (2004-2007)
  • Awarded JRF from Council of Scientific  and Industrial Research, New  Delhi, 1999
  • Employee Recognition Award-2006 for outstanding research productivity at MD Anderson Cancer Center, Houston USA
  • AMZEN Award in Basic Science Research-2007 at MD Anderson Cancer Center, Houston, USA
  • Innovative Young Biotechnologist Award (IYBA)-2009, DBT- India
  • BOYSCAST Fellow-2009, DST India (visiting scientist at Terry Fox Laboratory, Vancouver, Canada)
  • Young Scientist Award 2009 (Fast Track grant) –DST, India

 Brief description of research project

The main focus of my research is to understand the molecular mechanisms of signal transduction, gene regulation and the functionality of oncogenes in the development of human cancers. Mechanistic understanding of these issues is critical for rational approaches to combat human cancers. We recently identified a novel estrogen receptor interacting protein, PBXIP1/HPIP. HPIP is a microtubule binding protein with scaffolding activity regulates PI3Kinase/AKT and Src kinase/MAPK in breast cancer cells (Manavathi et al., 2006). Interestingly, HPIP over expression exhibits oncogenic properties in mammary epithelial cells. Further we found the over expression of HPIP in many infiltrative ductal breast adenocarcinoma patients. However, little is known about its cellular and physiological functions.  Therefore, biochemical characterization of HPIP/PBXIP1 functions would facilitate new strategies in molecular therapies to treat breast cancer patients.

 Selected publications

  • Kumar R, Balasenthil S, Manavathi B, Rayala SK, Pakala (2010) Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor. SB. Cancer Research, 70(16):6649-58.
  • Nair BC, Nair SS, Chakravarty D, Challa R, Manavathi B, Yew PR, Kumar R, Tekmal R and Vadlamudi RK. (2010) CDK-mediated phosphorylation play a critical role in PELP1's oncogenic functions. Cancer Research, 70(18):7166-75.
  • Talukder AH, Li DQ, Manavathi B and Kumar R (2008) Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation. Oncogene, 27(39):5233-42
  • Manavathi B, Singh K and Kumar R (2007) MTA family of coregulators in nuclear receptor biology and pathology. Nuclear Receptor Signaling, 5: e010.
  • Manavathi B, Peng S, Rayala SK, Wang G, Aggarwal N, Talukder AH, Balasenthil S, Frishman L, Kumar R (2007) Repression of Six3 by a corepressor regulates rhodopsin expression. Proc Natl Acad Sci USA (PNAS), 104(32):13128-33
  • Manavathi B, Rayala SK and Kumar R (2007) Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase. J Biol Chem, 282(27):19820-30
  • Manavathi B and Kumar R (2007) Metastasis tumor antigens, an emerging family of multifaceted master coregulators. J Biol Chem, 282(3):1529-33
  • Manavathi B, Acconcia F, Rayala SK and Kumar R. (2006) An inherent role of microtubule network in the action of nuclear receptor. Proc Natl Acad Sci USA (PNAS), 103(43):15981-6.
  • Manavathi B and Kumar R. (2006) Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin. J Cell Physiol, 207(3):594-604
  • Acconcia F, Manavathi B, Mascarenhas J, Talukder AH, Mills G and Kumar R. (2006) An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration. Cancer Res, 66(22):11030-8.
  • Rayala SK, Den Hollander P, Manavathi B, Talukder AH, Song C, Peng and Kumar R. (2006) Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. J Biol Chem, 281(28):19092-9.
  • Manavathi B, Nair SS, Wang RA, Kumar R, Vadlamudi RK. (2005) Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation. Cancer Res, 65(13):5571-7
  • Vadlamudi RK, Manavathi B, Balasenthil S, Nair SS, Yang Z, Sahin AA and Kumar R. (2005) Functional implications of altered subcellular localization of PELP1 in breast cancer cells. Cancer Res, 65(17):7724-32.
  • Vadlamudi RK, Manavathi B, Singh RR, Nguyen D and Kumar R. (2005) An essential role of Pak1 phosphorylation of SHARP in Notch signaling. Oncogene, 24(28):4591-6.
  • Verma A, Wang H, Manavathi B, Fok JH, Mann AP, Kumar R and Mehta K. (2006) Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis. Cancer Res, 66(21):10525-33.